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On his return, he studied the "Australian disease", which later became known as Murray Valley encephalitis.
At the Hall Institute he initially worked on the viruses that cause influenza and Murray Valley encephalitis.
There have been a number of deaths and serious illnesses from Murray Valley Encephalitis in several States/Territories in 2011.
It is the causal agent of Murray Valley encephalitis (previously known as Australian encephalitis) and in humans can cause permanent neurological disease or death.
Murray Valley encephalitis virus (MVEV)
Both forms of Kunjin virus disease are milder than the diseases caused by West Nile virus and Murray Valley encephalitis virus.
The continued rain and mild conditions (warm in the south, cool in the tropics) led to an outbreak of Murray Valley encephalitis which killed 19 people during the subsequent summer.
They include Murray Valley encephalitis in Australia, Japanese encephalitis, and Rocio virus in Brazil and Argentina.
Murray Valley encephalitis virus (MVEV) is a zoonotic flavivirus endemic to northern Australia and Papua New Guinea.
In 1960, QIMR scientists isolated Murray Valley encephalitis virus from mosquitoes, which paved the way for discovery of other arboviruses like Ross River virus in 1963.
Virologists including Alick Isaacs, Gordon Ada, John Cairns, Stephen Fazekas de St. Groth, and Frank Fenner made significant contributions on Murray Valley encephalitis, myxomatosis, poliomyelitis, poxviruses, herpes and influenza.