Mallory body

Mallory bodies are highly eosinophilic and thus appear pink on H&E stain.

Mallory bodies are classically found in the livers of people suffering from alcoholic liver disease and were once thought to be specific for that.

These cells to hepatocytes with Mallory bodies.

The Lewy bodies and Mallory bodies are examples of eosinophilic structures.

Some structures seen inside cells are described as being eosinophilic, for example, Lewy bodies, Mallory bodies.

Liver biopsy may show hepatocyte necrosis, Mallory bodies, neutrophilic infiltration with perivenular inflammation.

The presence of micronodular cirrhosis, Mallory bodies and fatty change within a single biopsy are highly suggestive of alcoholic injury.

In histopathology, a Mallory body, Mallory-Denk body, and Mallory's hyaline, is an inclusion found in the cytoplasm of liver cells.

Steatohepatitis is characterized microscopically by hepatic fat accumulation (steatosis), mixed lobular inflammation, ballooning degeneration of hepatocytes (sometimes with identifiable Mallory bodies), glycogenated hepatocyte nuclei, and pericellular fibrosis.

Frank Burr Mallory (1862-1941) was an American pathologist at the Boston City Hospital and Professor of Pathology at Harvard Medical School, after whom the Mallory body is named.

Severe NAFLD leads to inflammation, a state referred to as non-alcoholic steatohepatitis (NASH), which on biopsy of the liver resembles alcoholic hepatitis (with fat droplets and inflammatory cells, but usually no Mallory bodies).