Lassa virus

However, overall only about 1% of infections with Lassa virus result in death.

Upon entry, the Lassa virus infects almost every tissue in the human body.

In what animal host is Lassa virus maintained?

The cause of the illness was found to be Lassa virus, named after the town in Nigeria where the first cases originated.

Lassa virus is spread to humans primarily through contact with the excreta of infected rodents.

All these factors together contribute to the relatively efficient spread of Lassa virus from infected rodents to humans.

The life cycle of Lassa virus is similar to the Old World arenaviruses.

Lassa virus enters the cell by the receptor-mediated endocytosis.

In addition, there are at least four different strains of the Lassa virus, and an ideal vaccine should provide protection across all strains.

Currently there is no US licensed vaccine for humans against the Lassa virus.

Replication for Lassa virus is very rapid, while also demonstrating temporal control in replication.

The well-known Lassa fever is mostly caused by the Lassa virus.

Old World arena viruses include lymphocytic choriomeningitis virus, and Lassa virus.

Lassa virus electron micrograph.

Lassa virus is an emerging virus and a select agent, requiring Biosafety Level 4-equivalent containment.

Also, it is reported that Lassa virus prevents a host†s innate immune system by NP activity.

The Lassa Virus affects adults and children alike; no matter your age you can be at risk for Lassa.

The next member of the virus family to be associated with an outbreak of human illness was Lassa virus in Africa in 1969.

For example, when the Old World Lassa virus turns into Lassa fever, this usually results in a significant amount of mortality.

NP of Lassa virus is reported to have an exonuclease activity to only dsRNAs.

Lassa fever is an acute viral disease caused by Lassa virus, an arenavirus that is found throughout much of western Africa.

The reservoir, or host, of Lassa virus is a rodent known as the "multimammate rat" of the genus Mastomys.

Lassa viruses are enveloped, single-stranded, bisegmented, ambisense RNA viruses.

The specific transmission vector is not known, but is suspected to be a rodent, in keeping with other members of the arenavirus family, which includes the Lassa virus.

Evaluation of Lassa virus vaccine immunogenicity in the CBA/J-ML29 mouse model is ongoing.