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In Hirschprung's disease, the migration is not complete and part of the colon lacks these nerve bodies that regulate the activity of the colon.
New understandings of the way the second brain works, and the interactions between the two, are helping to treat disorders like constipation, ulcers and Hirschprung's disease.
In December 2012 a Crowdtilt campaign was created for Tony Forte, a 7 year-old with Total colonic Hirschprung's Disease.
Since Down Syndrome is comorbid in two percent of Hirschsprung's cases, there is a likelihood that RET is involved heavily in both Hirschprung's disease and Down Syndrome.