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It has been associated with the Hippo signaling pathway.
The Hippo signaling pathway appears to be highly conserved.
Tafazzin is a component of the hippo signaling pathway that controls tissue growth in animals.
The Hippo signaling pathway is involved in restraining cell proliferation and promoting apoptosis.
Today, the WW domain is known to mediate critical signals in tumor suppressor networks, including the Hippo signaling pathway.
Recent genetic studies in Drosophila have shown that the Hippo signaling pathway plays a key role in restricting organ size by controlling both cell proliferation and apoptosis.
(2013) Willin, an Upstream Component of the Hippo Signaling Pathway, Orchestrates Mammalian Peripheral Nerve Fibroblasts.
Many of the genes involved in the Hippo signaling pathway are recognized as tumor suppressors, while Yki/YAP/TAZ is identified as an oncogene.
The Hippo signaling pathway, also known as the Salvador/Warts/Hippo (SWH) pathway, controls organ size in animals through the regulation of cell proliferation and apoptosis.
The Hippo signaling pathway also tends to be directly linked with the BANTAM microRNA as it regulates it to control the functionality of cell proliferation and survival.
It is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.