Hailey-Hailey disease
benign familial pemphigus

It has also been used for vitiligo and Hailey-Hailey disease.

Hailey-Hailey disease is not an autoimmune disorder and there are no autoantibodies.

Hailey-Hailey disease is a distinct genetic disorder caused by a gene mutation.

Hailey-Hailey disease is also known as familial benign pemphigus, which has created significant confusion in the medical literature.

Similar outbreaks occur with Hailey-Hailey disease, though the cause is not autoimmune, but, rather genetic.

The symptoms and skin damage of pemphigus and Hailey-Hailey disease are similar.

Hailey-Hailey disease occurs due to a mutation in a specific gene that creates a protein that is essential for the proper health of skin.

Hailey-Hailey disease (familial benign pemphigus)

Note that Hailey-Hailey disease, also called familial benign pemphigus, is an inherited (genetic) skin disease, not an autoimmune disease.

The symptoms of Hailey-Hailey disease occur because of the failure of skin cells to stick together resulting in the breakdown of affected skin layers.

Breakdown of desmosomes by another mechanism (possibly protease activity) gives rise to the inherited Darier's disease and Hailey-Hailey disease, which are similar but probably unrelated.

Relapsing linear acantholytic dermatosis is a cutaneous condition characterized by relapsing linear erosions and crusting, histologically identical to Hailey-Hailey disease.

Benign familial pemphigus (Hailey-Hailey disease)