Grignard reaction

It's a lot easier to get the Grignard reaction going if you exclude water from the equipment.

Many methods have been developed to initiate Grignard reactions that are slow to start.

The 2-methylbenzhydryl chloride can be formed via a Grignard reaction.

This reaction can limit the utility of Grignard reactions.

The Grignard reaction is an important tool in the formation of carbon-carbon bonds.

This synthesis was the best way to make alcohols until the advent of the Grignard reaction in 1901.

Typical Grignard reactions involve the use of magnesium ribbon.

The Grignard reaction is an important means of preparing organic compounds from smaller precursor molecules.

Secondly, Grignard reactions, while exothermic, are typically conducted at low temperature for better selectivity.

An example of the Grignard reaction is a key step in the industrial production of Tamoxifen.

For derivatives with phenyl or vinyl substituent, the Grignard reaction is employed.

It is also a common solvent for the Grignard reaction in addition to other reactions involving organometallic reagents.

In the second step the 2-(1-piperidino)propiophenone is reacted with cyclohexylmagnesiumbromide in a Grignard reaction.

Grignard reactions often start slowly.

The Grignard reaction produces a carbon-carbon bond.

Grignard reactions will not work if water is present; water causes the reagent to rapidly decompose.

The Grignard reaction does not have this advantage because it is so reactive that it attacks indiscriminately from both sides.

Grignard reactions are exothermic, and this exothermicity must be considered when a reaction is scaled-up from laboratory to production plant.

Grignard reactions are not ionic.

Grignard reaction, an organic chemical reaction developed by Victor Grignard.

It is also the product of the Grignard reaction of propylmagnesium bromide with propionitrile:

For these two reasons, Grignard reactions often can have a long induction period, followed by a thermal runaway, even causing the reaction solvent to boil-off.

Therefore, these reactions represent Green chemistry, providing a safer alternative to the very common Grignard reaction, performed with Mg.

Desiccants are also used to dry solvents, typically used for moisture free reactions (e.g. the Grignard reaction).

A Grignard reaction involving methylmagnesium bromide provided alcohol 4, which was subjected to acid catalyzed elimination to give diene 5.