griffithsin , GRFT (Abkürzung)

A cigarette containing griffithsin hasn't been discounted either, said Palmer.

The scientists harvested the plants by hand and processed them to extract the griffithsin.

The chemical performed identically to griffithsin produced by other methods, the report said.

Griffithsin is a protein isolated from the red algae Griffithsia.

A 2014 study showed griffithsin to also possess useful antiviral activity against Ebolavirus.

Griffithsin, a substance derived from algae, appears to have entry inhibitor properties.

Scytovirin and griffithsin are currently being investigated as potential microbicides for topical use.

The scientists first mail-ordered a synthetic version of the red algae gene that produces griffithsin.

Griffithsin shows a broad spectrum ability to bind to the glycoproteins of other viruses, such as the coronavirus.

What has prevented griffithsin from becoming a standard HIV preventive measure is the cost of producing it.

Griffithsin, an anti-viral lectin from red algae (Griffithsia species).

They were able to extract enough griffithsin to produce about 100,000 HIV microbicide doses from the leaves.

They modified the tobacco mosaic virus to incorporate the griffithsin gene and infected more than 9,300 tobacco plants.

Griffithsin's three identical carbohydrate domains bind to specific oligosaccharides on the envelope of viral glycoproteins.

Tobacco-derived griffithsin in a gel has already been tested in both mice and in the cells of women who have had their cervix removed.

In both cases the griffithsin stopped all HIV transmission without any toxic side effects and without any sign of inflammation or irritation.

Scientists have known for years that the drug, known as griffithsin, protects some people from HIV infection by stopping the virus from colonizing the vaginal lining.

The only known naturally occurring source of griffithsin is a red algae found off the coast of New Zealand, which grows in amounts too small to be effectively harvested.

For instance, it was shown that griffithsin binds to the SARS-CoV spike glycoprotein to inhibit entry of the SARS virus and thus inhibit infection.

Scientists can produce larger amounts of griffithsin by genetically engineering E. coli bacteria to produce the drug, but maintaining the necessarily high temperatures, supplying the raw materials, and harvesting the drug is expensive.

While some lectins such as cyanovirin and Urtica dioica agglutinin are thought likely to be too allergenic to be used internally in humans, studies so far on scytovirin and griffithsin have not shown a similar level of immunogenicity.

Lack of available treatment options has spurred research into a number of other possible antivirals targeted against Ebola, including natural products such as scytovirin and griffithsin, as well as synthetic drugs including DZNep, FGI-103, FGI-104, FGI-106, dUY11 and LJ-001, and other newer agents.

The GRFT organization is based in Knoxville, Tennessee and operates throughout Northeast Tennessee.

I would propose that the "Reliability Tax" modeled after the Gross Receipts and Franchise Tax (GRFT) and would be an additional line item on a utility's bill.

As a separate line item on the utility's bill and presented as a tax, the state regulators would have as much of a role in this tax as they have (or had) in the GRFT.