The disease Fibrodysplasia ossificans progressiva causes people to have a small hallux.

Learn more with the 3 fibrodysplasia ossificans progressiva videos in this playlist.

Fibrodysplasia ossificans progressiva usually begins during early childhood and progresses throughout life.

Isotretinoin has been used to treat the extremely rare condition fibrodysplasia ossificans progressiva.

Fibrodysplasia ossificans progressiva, a rare disease in which fibrous tissue such as muscle turns to bone when damaged.

Sufferers of fibrodysplasia ossificans progressiva remain healthy inside, but their muscles and tendons ossify, leaving them paralyzed.

That's what happens with Fibrodysplasia Ossificans Progressiva, or FOP.

As a consequence it is being evaluated in several human clinical trials for cancer, macular degeneration, diabetic retinopathy, and fibrodysplasia ossificans progressiva.

People with the rare genetic disease fibrodysplasia ossificans progressiva characteristically have a short hallux which appears to turn inward, or medially, in relation to the foot.

Human Mutants: Fibrodysplasia Ossificans Progressiva (02:40)

Proceeds benefit the International Fibrodysplasia Ossificans Progressiva Association for research in a genetic condition that turns connective tissue into bone.

Fibrodysplasia ossificans progressiva (FOP), sometimes referred to as Stone Man Syndrome, is an extremely rare disease of the connective tissue.

Increase in expression of BMP4 has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.

How Fibrodysplasia Ossificans Progressiva (FOP) Works What if your muscles, tendons and ligaments turned to bone?

ONLY one person in two million is born with fibrodysplasia ossificans progressiva, a rare genetic disorder in which bones grow uncontrollably to the point of causing devastating disability.

This year that show featured a story about a patient with fibrodysplasia ossificans progressiva, a disorder in which damaged muscles and connective tissue turn to bone, forming, essentially, a second skeleton.

In 2006, Drs. Kaplan and Shore of the Department of Orthopedics discovered the causative mutation in fibrodysplasia ossificans progressiva, an extremely rare disease of bone.

On Discovery Channel's "Human Mutants: The Mystery of Growth," learn about Fibrodysplasia Ossificans Progressiva (FOP) and methods scientists use to research this disease.

We meet Carole Ozel, who copes with extraordinary courage with a terrible disease called fibrodysplasia ossificans progressiva (FOP), in which bony tissue forms throughout the body, gradually immobilizing the body in a second skeleton.

The second condition, myositis ossificans progressiva (also referred to as fibrodysplasia ossificans progressiva) is an inherited affliction, autosomal dominant pattern, in which the ossification can occur without injury, and typically grows in a predictable pattern.

Hayden suffers from a condition called fibrodysplasia ossificans progressiva, or F.O.P. Exceedingly rare, it is one of medicine's ugliest bogeymen: beginning in early childhood, the muscle, tendons and connective tissue of those afflicted simply morph into bone.

He was the first to record the genetic error that causes fibrodysplasia ossificans progressiva, and his 1748 Essay on the Art of Healing identified points of interest of breast cancer and referred to the danger of not removing infected lymphatic tissue.

Harry Raymond Eastlack, Jr. (1933 - 1973) suffered from fibrodysplasia ossificans progressiva (FOP), a rare and poorly understood disease in which the bone repair mechanism runs out of control, turning other tissue like muscles and tendons into bone.

In 1942, while the Museum was in Erie, Pennsylvania, Harry Lewiston's performing "stone man" Charles Porter visited a famous local resident also suffering from the disease (likely Fibrodysplasia ossificans progressiva), and they were profiled in the local paper.

C. Vyaghreswarudu, R. J. Reddy: Myositis ossificans progressiva: report of two cases.

There is another variant called myositis ossificans progressiva, a rare, genetic disorder, in which there are recurrent episodes of inflammation around the big toe, which eventually lead to ossification in the area and deformity of the toe.

The second condition, myositis ossificans progressiva (also referred to as fibrodysplasia ossificans progressiva) is an inherited affliction, autosomal dominant pattern, in which the ossification can occur without injury, and typically grows in a predictable pattern.

He'd put a lot of work into being a fop.

A fop he might be, but likely enough a dangerous one.

This seemed to put the fop almost into good humor again.

And Randolph had seemed to be no more than a court fop.

"From what you say of this fop, he could not care less."

The technician might be a fop, but he also seemed to know his business.

Now it'd be left to some young fop to lead her to the altar.

If so, why the hell had she married the fop instead of waiting for his own return?

What a fop to get up his gloves in this style!

He'd made her believe that he was a bored fop with time hanging on his hands.

He is a fop and a runner who has not joined in one battle so far.

And she'd already discovered that despite the fop appearance, he could handle problems.

I began to labour very hard to make myself into a fop, cad.

"I think it is the letter of a fop," said my father, bluntly.

Replacing a hyperactive little man by a polo playing fop.

He had not been impressed by the drunken fop.

I sold it to a court fop for twice what it was worth.

She then slipped away from her partner and padded silently down the street after the fop.

The rich baritone voice and hardened body belonged to no local fop.

The fop of fields is no better than his brother of Broadway.

And since then the elderly fop drives up to the shop almost every day to drink beer.

He's no mincing fop but a man caught in what is finally an unequal struggle.

Dropping it, Kirk shifted sword hands and closed on the second fop.

Kirk didn't make the mistake of dismissing him as a fop, however.

The fop shook his head and went outside.