Darzens reaction

For these, the related Darzens reaction is typically more appropriate.

The product of the Darzens reaction can be reacted further to form various types of compounds.

An intramolecular epoxide formation reaction is one of the key steps in the Darzens reaction.

This method of synthesis can be used to produce a variety of aldehydes and became known as the Darzens reaction and is still used today.

Examples include the synthesis of oxazoline rings and the Darzens reaction (shown below) which proceeds via an internal nucleophilic substitution.

The asymmetric Darzens reaction between aldehydes and (alpha)-haloesters is an effective method for the synthesis of glycidic esters.

Reaction with ethyl chloroacetate (Darzens reaction) gave the α,β-epoxy ester, which was hydrolyzed and decarboxylated to the aldehyde.

Chiral auxiliaries, chiral boron enolates, and asymmetric phase transfer catalysis have been used successfully to effect asymmetric induction in the Darzens reaction.

In 1904 he discovered the Darzens reaction, a chemical reaction also known as the Darzens condensation and Darzens glycidic ester condensation.

The Darzens reaction (also known as the Darzens condensation or glycidic ester condensation) is the chemical reaction of a ketone or aldehyde with an α-haloester in the presence of base to form an α,β-epoxy ester, also called a "glycidic ester".