Dalrymple's sign

The fissure may be increased in vertical height in Graves' disease, which is manifested as Dalrymple's sign.

It is accompanied by Dalrymple's sign, which is a retraction of the upper eyelids resulting in an apparent widening of the palpebral opening.

The eponymous Dalrymple's sign is named after him, which is an abnormal wideness of the palpebral fissures in exophthalmic goiter.

Dalrymple's sign is a widened palpebral (eyelid) opening, or eyelid spasm, seen in thyrotoxicosis (as seen in Graves' disease, exophthalmic Goitre and other hyperthyroid conditions), causing abnormal wideness of the palpebral fissure.