DNA binding domain

Nevertheless, it is thought to be a DNA binding domain despite its beta structure.

Expression of the 140k DNA binding domain in E.coli.

They are classified to families, classes and superclasses according to the features of their DNA binding domains.

There is limited similarity outside the ETS DNA binding domain.

From this deletion analysis we conclude that the minimal DNA binding domain of the 140k protein lies within residues 472 to 633.

Thus, regions outside of the minimal DNA binding domain were required for transcriptional activation in a reconstituted transcription system.

SHP is unusual for a nuclear receptor in that it lacks a DNA binding domain.

It has a DNA binding domain and a PNT (pointed) domain.

The C-finger, named for being near the C-terminal, has a Zinc finger DNA binding domain.

This is mainly because the domains exhibiting the transactivation properties and those controlling nuclear association are located in regions flanking the central DNA binding domain.

Other artificial restriction enzymes are based on the DNA binding domain of TAL effectors.

Regions outside of the NHR and DNA binding domain are thought to contain transcriptional activation domains.

One sequence (B42), 72 residues long, was shown to function as an activator when transferred to the lexA DNA binding domain.

The DNA binding domain of 140k was cloned into the T7 expression vector p585T7a, as described in detail in the materials and methods section.

The protein has a transactivation domain linked by a relatively unstructured hinge region to a well-characterized DNA binding domain.

The DNA binding domain contains a repeated highly conserved 33-34 amino acid sequence with the exception of the 12th and 13th amino acids.

Most of these mutations in p53 are located in DNA binding domain of the protein and have a dominant-negative effect over alternate wild type alleles.

Methionine residues are high-lighted; the POU DNA binding domain is printed in bold face type.

Therefore it is reasonable to assume that the binding properties of the 140k DNA binding domain presented here reflect those of the full 140k polypeptide.

This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species.

A coactivator is a protein that increases gene expression by binding to an activator (or transcription factor) which contains a DNA binding domain.

A. Schematic diagram of the deletion constructs of the VZV 140k DNA binding domain.

Transcription factors with zinc finger DNA binding domains, such as the GATA family and glucocorticoid receptor.

Common examples include the SH3 domain, the beta-propeller domain, the immunoglobulin fold and B3 DNA binding domain.

An exon 7 skipping splice variant encodes a shorter form of the protein which lacks the first two zinc fingers of the DNA binding domain.