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The process of DNA methylation is thought to be behind such changes.
The change may be in the pattern of DNA methylation, for example.
DNA methylation may affect the transcription of genes in two ways.
DNA methylation was the first discovered epigenetic mark, and remains the most studied.
DNA methylation patterns vary greatly between species and even within the same organism.
DNA methylation may be necessary for normal growth from embryonic stages in mammals.
During development, the human DNA methylation profile experiences dramatic changes.
DNA methylation also plays a crucial role in the development of nearly all types of cancer.
DNA methylation serves a wide variety of biological functions.
Are dietary factors involved in DNA methylation associated with colon cancer?
This link between DNA methylation and chromatin structure is very important.
Disease condition studies have largely fueled the effort in understanding the role of DNA methylation.
Within an organism, DNA methylation levels can also vary throughout development and by region.
Normally, oncogenes are silent, for example, because of DNA methylation.
Prominent among these, was DNA methylation, or lack thereof.
DNA methylation and histone modification have been implicated in the regulation of this process.
A hypomethylating agent is a drug that inhibits DNA methylation.
This method is based on DNA methylation analysis.
DNA methylation inhibitors are used to activate previously silenced genes.
Research has suggested that long-term memory storage in humans may be regulated by DNA methylation.
DNA methylation can be detected by the following assays currently used in scientific research:
DNA methylation can also be detected by computational models through sophisticated algorithms and methods.
DNA methylation involves the addition of a methyl group to a 5' cytosine residue.
Together with similar modifications such as DNA methylation it is part of the epigenetic code.
Key contributions to biomarker science based on DNA methylation include: