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D-dimer is highly sensitive but not very specific (specificity around 50%).
In interpretation of the d-dimer, for patients over age 50 a value of ageX10 may be abnormal.
A D-dimer (product of thrombi degradation) test can be specified separately.
For some of these, the area of the D-dimer to which the antibody binds is known.
Furthermore, the level of the D-dimer correlated with the extent of the thrombosis.
D-dimer (when suspicion for pulmonary embolism is present but low)
There was an elevated d-dimer of 17.54 mg/mL and platelets were slightly decreased.
If the probability of PE is considered low, a blood test called D-dimer may be requested.
The study concludes that D-dimer is not useful in the situations where it would make the most difference, namely in lower probability cases.
Several detection kits are commercially available; all of them rely on a different monoclonal antibody against D-dimer.
The diagnosis can be confirmed with standard blood tests for DIC, such as D-dimer.
If positive D-dimer, obtain MDCT and based treatment on results.
If negative D-dimer, PE is excluded.
A blood D-dimer level less than 500 mcg/mL may be able to rule out the diagnosis of aortic dissection alleviating the need for further imaging.
The typical D-dimer containing fragment contains two D domains and one E domain of the original fibrinogen molecule.
FDPs, and a specific FDP, the D-dimer, can be measured using antibody-antigen technology.
Five hours after being bitten, his blood had a normal platelet count, but was incoagulable with a reduced fibrinogen concentration, elevated fibrin degradation products and D-dimer.
D-dimer, fibrin and fibrinogen degradation products were also high initially and then decreased, whilst renal function improved to normal on day 14 and remained so.
High levels of fibrin degradation products, including D-dimer, are found owing to the intense fibrinolytic activity stimulated by the presence of fibrin in the circulation.
However, the authors were not concerned that a negative MDCT with negative D-dimer in this setting has an 5% probability of being false.
Since the D-dimer can exclude the need for imaging, specialty professional organizations recommend that physicians use D-dimer testing as an initial diagnostic.
D-dimer is a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis.
If the D-dimer reads high, then further testing (ultrasound of the leg veins or lung scintigraphy or CT scanning) is required to confirm the presence of thrombus.
For several days after AMI, the levels of tissue factor and D-dimer, which are involved in coagulation, are high, which increases the risk of LVT formation.
For a suspected first leg DVT in a moderate-probability scenario, a high-sensitivity D-dimer is suggested as a recommended option over ultrasound imaging, with both whole-leg and compression ultrasound possible.