D gene

However, the d gene was hypothetical, not actual.

It is included in a cluster of homeobox D genes located on chromosome 2.

The light chains also possess numerous V and J gene segments, but do not have D gene segments.

In this case, cyclin D gene has been translocated to the parathyroid hormone gene, and this event caused abnormal levels of cyclin D.

Rho family GTPases and focal adhesion kinase (FAK) activate cyclin D gene in response to integrin.

This system was based on the theory that a separate gene controls the product of each corresponding antigen (e.g., a "D gene" produces D antigen, and so on).

NAPE-PLD was found to have no homology to the known phospholipase D genes, but can be classed by homology to fall into the zinc metallohydrolase family of the beta-lactamase fold.

The Ea expression level obtained with the Long construct mice approaches the actual ratio of that seen in BALB/c mice of one times the expression level per genomic copy of the Ea d gene.

The MAP kinase ERK activates the downstream transcription factors Myc and AP-1 which in turn activate the transcription of the Cdk4, Cdk6 and cyclin D genes, and increase ribosome biogenesis.

We show that position-independent, copy number-dependent expression of the Ea d gene occurs only with the Long construct (8/8 transgenic mouse lines, over a range of copy numbers, 1-30 copies); in contrast, the Short constructs are subject to position-dependent effects.

Significantly, 20% and 40% of the hits derived from KRC/ZAS-N and KRC/ZAS-C, respectively, came from the D gene segments of the variable region of human or mouse Ig heavy chains.

To determine whether the Ea DH groups I-V define a functionally important chromatin domain or locus control region (LCR), we have used wild type Ea d gene constructs to generate transgenic mouse lines from strains that do not express an endogenous Ea gene product.