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The underlying cause of Coffin-Siris syndrome is unknown.
Coffin-Siris Syndrome is a rare genetic disorder which causes developmental delays and absent fifth finger and toe nails.
Dwarfism-Onychodysplasia Fifth Digit Syndrome Mental Retardation with Hypoplastic 5th Fingernails and Toenails Short Stature-Onychodysplasia None Coffin-Siris syndrome is a rare genetic disorder that may be evident at birth (congenital).