Clostridium histolyticum

It was isolated from Clostridium histolyticum.

Clostridium histolyticum produces large endospores and are asaccharolytic and proteolytic.

Clostridium histolyticum can be isolated from soil during the early stage of soil cultivation, by heating the sample at 60 C for 30 minutes.

Clostridium histolyticum is difficult to culture because growth is inhibited by sugars and spores are not very heat resistant.

Clostridium histolyticum produces five toxins: alpha, beta, gamma, delta, and epsilon.

Six species of metalloendopeptidase acting on native collagen can be isolated from the medium of Clostridium histolyticum.

Collagenase clostridium histolyticum is secreted by the bacteria and can destroy connective tissue of muscles.

This enzyme is secreted enzyme from Clostridium histolyticum.

Clostridium histolyticum secretes potent exotoxins that have proteolytic and necrotizing properties, causing severe local necrosis.

While gas gangrene is easily diagnosed by the visible necrosis and characteristic smell, identifying Clostridium histolyticum as the causative agent is more difficult.

Clostridium histolyticum proteinases, including gamma- and delta-toxin, digest native and denatured proteins to amino acids with the production of ammonia.

Studies have shown that injection of collagenase clostridium histolyticum significantly reduces the contractures by lysing the collagen and disrupting the contracted cords.

The injection for PIP also consist of one injection but filled with 0.58 mg collagenase clostridium histolyticum/ 0.20 ml.

Collagenase clostridium histolyticum is manufactured and marketed as Xiaflex by Pfizer and Auxilium Pharmaceuticals.

Thomas A, Bayat A., The emerging role of Clostridium histolyticum collagenase in the treatment of Dupuytren disease.

Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum that dismantles collagen.

In 1922, Heller renamed the bacterium Weinbergillus histolyticus, and a year later Bergey, Harrison, et al. reclassified it as Clostridium histolyticum.

Collagenase (Clostridium histolyticum ) was purchased from Boehringer Mannheim Ltd, Lewes, East Sussex, UK.

Studies have shown that the toxigenicity of a strain of Clostridium histolyticum is directly related to its sporulating potency: the higher the sporulating potency, the more toxigenic the strain.

In February 2010 the US Food and Drug Administration (FDA) approved injectable collagenase extracted from Clostridium histolyticum for the treatment of Dupuytren's contracture.

Collagenase clostridium histolyticum (marketed as Xiaflex by Auxilium), a drug approved by the FDA to treat Dupuytren's contracture, has been reported to break down the excess collagen that causes Peyronie's disease.

A 2002 study of the intestinal flora of inflammatory bowel disease (IBD) patients found that in patients who had ulcerative colitis, a form of IBD, 21% of the total bacteria in the colon were Clostridium histolyticum.