Claisen condensation

The second addition occurs through a Claisen condensation.

The reaction is known as the Claisen condensation.

It is prepared via the Claisen condensation of ethyl acetate.

The key step in the assembly of quinotoxine is a claisen condensation:

In nature, polyketides are synthesized by enzymes that effect iterative Claisen condensations.

A Claisen condensation involves two ester compounds.

Sodium ethoxide is commonly used in the Claisen condensation and malonic ester synthesis.

Crossed Claisen condensations, in which the enolate and nucleophile are different esters, are also possible.

The classic Claisen condensation, a self-condensation between two molecules of a compound containing an enolizable ester.

Discovered (1887) the condensation reaction of an ester with an activated methylene group, now known as the Claisen condensation.

This produces a racemic mixture of the 2-substituted pyrrolidine, with the retention of the thioester from the Claisen condensation.

The last step of the procedure appears to be a Dieckmann cyclization (intramolecular Claisen condensation) followed by decarboxylation.

A Claisen condensation closed the ring to 1.8 and the intermediate enol is captured by pivaloyl chloride (piv) as a protective group.

The thiolase superfamily enzymes catalyse the carbon-carbon-bond formation via a thioester-dependent Claisen condensation reaction mechanism.

The final step is a claisen condensation of 15 with ethyl quininate 16, which after acidic workup yields racemic quinotoxine 17.

Enols are commonly used in condensation reactions, including the Claisen condensation and the aldol condensation reactions.

Later another SxtA performs a Claisen condensation reaction between propionyl-ACP and arginine producing 4.

There are a number of different combinations of enolizable and nonenolizable carbonyl compounds that form a few different types of Claisen condensations.

They are synthesized by a series of decarboxylative Claisen condensation reactions from acetyl-CoA and malonyl-CoA.

In the Claisen condensation, an enolate of one ester (1) will attack the carbonyl group of another ester (2) to give tetrahedral intermediate 3.

After the generation of a thioester-linked tetraketide, a regiospecific C1,C6 Claisen condensation occurs, forming a new ring system to generate naringenin chalcone.

In mixed Claisen condensations, a non-nucleophilic base such as lithium diisopropylamide, or LDA, may be used, since only one compound is enolizable.

The mixed (or "crossed") Claisen condensation, where one enolizable ester or ketone and one nonenolizable ester are used.