It is an immunoglobulin G-kappa (IgGκ) consisting of human constant regions and murine complementarity-determining regions grafted onto human framework light and heavy chain variable regions.

The high affinity of protein G for the Fab portion of IgG poses a particular challenge in molecular recognition, given the variability of heavy chain subclass, light chain type and complementarity-determining regions.

Using this method, Wilchek collaborated with a team who proved that the binding site of antibodies lies in the Fv portion of the molecule and involves three hypervariable sites, today called the complementarity-determining regions (CDRs).

They discovered the "canonical-structure model" for the conformation of the complementarity-determining regions of antibodies, and they applied this model to the analysis of antibody-germ-line genes, including the prediction of the structure of the corresponding proteins.

"The police commander is a very important part of the community."

By the look on his face, the commander was about to ask another question.

But first, she was still a commander with a team.

I brought you here to ask for your help, Commander.

The commander would know what to do when the time came.

Soon, he would have enough to make a report to the commander.

The Commander had said she would use her, but how?

Should a commander lead the way or keep his eyes open?

Just a report I need to make to the commander.

In 2010 he was made a Commander of the same order.

I am their commander and must look out for them.

Their commander needed to be able to present them with a plan.

So, each commander simply gave the order when he thought the time was right.

He did not see the point his commander was working toward.

What might they do to him if something happened to their commander?

Much of what had made her a good commander was lost.

Not the kind of man you would meet often, Commander.

But as company commander, I was running my own little show.

"And if the Commander can answer these questions then he should do so."

Your commander is said to be a man of his word.

Perhaps in six weeks time he would be a commander again.

I am not certain what my Commander has in mind for our next move.

So the commander knew what he was trying to do.

The problem was, what could he say to his commander, no matter how long they had been friends as kids?

What would his commander do for him when he was too old to be of use?