Bowman's space

The barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman's space.

This layer acts as a selective macromolecular filter, preventing the passage of large protein molecules into Bowman's space.

The fluid that is filtered from the capillary blood into Bowman's space is called filtrate or primary urine.

Large and/or negatively charged proteins are prevented from passing into Bowman's space, thus retaining these proteins in the circulation.

Podocytes line the other side of the glomerular basement membrane and form part of the lining of Bowman's space.

Podocytes form a tight interdigitating network of foot processes (pedicels) that control the filtration of proteins from the capillary lumen into Bowman's space.

Any small molecules such as water, glucose, salt (NaCl), amino acids, and urea pass freely into Bowman's space, but cells, platelets and large proteins do not.

Bowman's space (or "urinary space", or "capsular space") - Between the visceral and parietal layers, into which the filtrate enters after passing through the filtration slits.

Most of the glomeruli show endothelial and mesangial proliferation affecting the entire glomerulus, leading to diffuse hypercellularity of the glomeruli, producing in some cases epithelial crescents that fill Bowman's space.

Cells, proteins, and other large molecules are filtered out of the glomerulus by a process of ultrafiltration, leaving an ultrafiltrate that resembles plasma (except that the ultrafiltrate has negligible plasma proteins) to enter Bowman's space.