Bence-Jones proteins are relatively small and are filtered out by the kidneys.

Urine immunofixation is the best test for detecting Bence-Jones proteins.

No presence of Bence-Jones proteins is normal.

Bence-Jones proteins are rarely found in urine, but if they are, they are usually associated with multiple myeloma.

Bence-Jones protein (quantitative)

Immunoglobulin light chains - urine; Urine Bence-Jones protein Collect a "clean-catch" (midstream) urine sample.

A quantitative Bence-Jones protein test measures the specific level of abnormal proteins (Bence-Jones proteins) in your urine.

False negatives may also occur if the protein in the urine is composed mainly of globulins or Bence-Jones proteins because the reagent on the test strips, bromphenol blue, is highly specific for albumin.

In November 1998, she was diagnosed with multiple myeloma, a form of blood cancer where plasma cells secrete abnormal antibodies known as Bence-Jones proteins, which can cause bones to disintegrate and dump toxic amounts of calcium into the bloodstream.

A major advance in these structural studies was the discovery in the early 1960s by Gerald Edelman and Joseph Gally of the antibody light chain, and their realization that this protein was the same as the Bence-Jones protein described in 1845 by Henry Bence Jones.

Bence Jones proteins are present in 2/3 of multiple myeloma cases.

The immunoglobulins may show up in the urine as Bence Jones proteins.

Abnormal light chains in blood and urine are sometimes referred to as "Bence Jones protein".

Monoclonal free light chains in the serum or urine are called Bence Jones proteins.

Light chains only (or Bence Jones protein).

Ig light chains produced in neoplastic plasma cells, such as in multiple myeloma, are called Bence Jones proteins.

Detection of Bence Jones protein may be suggestive of multiple myeloma or Waldenström's macroglobulinemia.

Plasma cell leukemia is more frequent in light-chain (Bence Jones protein) or IgD myeloma.

Results from characterization studies of urinary immunoglobulins indicate that light chains (Bence Jones protein), usually of the kappa type, are found in the urine.

One type of paraprotein is the Bence Jones protein which is a urinary paraprotein composed of free light chains (see below).

A Bence Jones protein is a monoclonal globulin protein or immunoglobulin light chain found in the urine, with a molecular weight of 22-24 kDa.

In 1847, he described the Bence Jones protein, a globulin protein found in blood and urine, suggestive of multiple myeloma or Waldenström's macroglobulinemia.

The Bence Jones protein was described by the English physician Henry Bence Jones in 1847 and published in 1848.

Dalrymple is remembered for his histological work done with Henry Bence Jones (1814-1873) in the discovery of the albumin that was to become known as Bence Jones protein.

Note that while most heavy chains or whole immunoglobulins remain within blood vessels, light chains frequently escape and are excreted by the kidneys into urine, where they take the name of Bence Jones protein.

In multiple myeloma, there is often protein cast in the distal convoluted tubule and collecting duct of the kidneys, mainly consisting of immunoglobulin light chain known as Bence Jones protein, but often also contain Tamm-Horsfall protein.

Bence Jones proteins are particularly diagnostic of multiple myeloma in the context of end-organ manifestations such as renal failure, lytic (or "punched out") bone lesions, anemia, or large numbers of plasma cells in the bone marrow of patients.

The hematologist, when first evaluating a case of MGUS, will usually perform a skeletal survey (X-rays of the proximal skeleton), check the blood for hypercalcemia and deterioration in renal function, check the urine for Bence Jones protein and perform a bone marrow biopsy.