ATP-binding cassette transporter

Cells that express specific ATP-binding cassette transporter proteins can also actively transport these stains out of their cytoplasm.

For example, some peptide autoinducers are secreted by ATP-binding cassette transporters that couple proteolytic processing and cellular export.

The ATP-binding cassette transporter is defective and leads to a build up of a toxic metabolite lipofuscin in the retinal pigmented epithelium.

ATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ABCC8 gene.

They are capable of picking up cholesterol, carried internally, from cells by interaction with the ATP-binding cassette transporter A1 (ABCA1).

ATP-binding cassette transporters import antimicrobial peptides and the resistance-nodulation cell-division efflux pump exports antimicrobial peptides.

ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes.

A gene encoding an ATP-binding cassette transporter was mapped to the 2-cM (centiMorgan) interval at 1p13-p21 previously shown by linkage analysis to harbor this gene.

Cholesterol from non-hepatic peripheral tissues is transferred to HDL by the ABCA1 (ATP-binding cassette transporter).

FepB,C,D and G all participate in transport of the FeEnt through the inner membrane by means of an ATP-binding cassette transporter.

ABC transporter transmembrane domain is main transmembrane structural unit of ATP-binding cassette transporter which consist of six transmembrane domaines.

ATP-binding cassette transporters (ABC-transporter) are members of a protein superfamily that is one of the largest and most ancient families with representatives in all extant phyla from prokaryotes to humans.

The release of prostaglandin has now also been shown to be mediated by a specific transporter, namely the multidrug resistance protein 4 (MRP4, ABCC4), a member of the ATP-binding cassette transporter superfamily.

ATP-binding cassette transporter ABCA1 (member 1 of human transporter sub-family ABCA), also known as the cholesterol efflux regulatory protein (CERP) is a protein which in humans is encoded by the ABCA1 gene.

It is likely that along with the Organic Anion Transporters, Organic Cation transporters and the ATP-binding cassette transporters, the OATPs play a central role in the absorption, distribution, metabolism and exretion (ADME) of drug compounds.

These proteins are members of the family of ATP-binding cassette transporters and can catalyse the ATP-dependent transport of a huge variety of hydrophobic anions, and thus act to remove phase II products to the extracellular medium, where they may be further metabolised or excreted.