He acted as Minister Resident to Venezuela in 1867 and 1868.
He was appointed Minister Resident to Colombia in 1869, where he served three years.
He was also appointed Minister Resident and consul general to Switzerland and served from 1885 to 1889.
Although with no international experience, as a representative of the US, the Minister Resident was one of the most powerful figures in the country.
He was Minister Resident and Consul General in Haiti from 1869 to 1877.
He was Minister Resident to Russia in 1715 to 1716.
In 1892 and 1893, Little was Minister Resident to Egypt.
He was appointed Minister Resident to Turkey and served from June 8, 1861, to October 25, 1870.
Washburn was appointed as Commissioner in 1861 and promoted to Minister Resident in 1863.
He was promoted to Minister Resident in 1883.